Affiliated Investigator: Associate Professor Duke NUS Medical School Carolyn S. P. Lam

MBBS, MRCP, PhD, MS

 

Associate Professor, Duke-NUS Medical School

 

Research Lab Profile:

Heart failure clinical and translational research

 

Research Theme: 

Heart Failure Clinical Studies 

 

 

 

 

 




GROUP MEMBERS

  • Lee Kim Yee
  • Nur Faezah Binte Md Fadzillah
  • Lu Tianmin
  • Xu Chang Fen
  • Eugene Tan
  • Lim Shir Lynn
  • Yeo Tee Joo
  • Michelle Chan
  • Rajalakshmi Santhanakrishnan

COLLABORATORS

  • Tze P Ng
  • Robert N Doughty
  • Vicky A Cameron
  • Greg D Gamble
  • Lieng H Ling
  • David Sim
  • Gerard Kui Toh Leong
  • Poh Shuan Daniel Yeo
  • Hean Yee Ong
  • Fazlur Jaufeerally
  • Raymond Ching-Chiew Wong
  • Ping Chai
  • Adrian F Low
  • Mayanna Lund
  • Gerry Devlin
  • Richard Troughton
  • Mark Richards
  • Inder Anand
  • Shu Zhang
  • Wataru Shimizu
  • Calambur Narasimhan
  • Sang Weon Park
  • Cheuk-Man Yu
  • Tachapong Ngarmukos
  • Razali Omar
  • Eugene B. Reyes
  • Bambang Siswanto
  • Margaret Redfield
  • Barry Borlaug
  • Javed Butler
  • Vasan Ramachandran
  • Scott Solomon
  • Amil Shah

PUBLICATIONS

1.    Michelle M.Y. Chan, Carolyn S.P. Lam. How Do Patients With Heart Failure And Preserved Ejection Fraction Die? Eur J Heart Fail. 2013 Jun;15(6):604-13

2.    Carolyn S.P. Lam, Inder Anand, Shu Zhang, Wataru Shimizu, Calambur Narasimhan, Sang Weon Park, Cheuk-Man Yu, Tachapong Ngarmukos, Razali Omar, Eugene B. Reyes, Bambang Siswanto, Lieng H. Ling, A Mark Richards. Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) Registry. Eur J Heart Fail. 2013 Aug;15(8):928-36

3.    Rajalakshmi Santhanakrishnan, Tze P Ng, Vicky A Cameron, Greg D Gamble, Lieng H Ling, David Sim, Gerard Kui Toh Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Raymond Ching-Chiew Wong, Ping Chai, Adrian F Low, Mayanna Lund, Gerry Devlin, Richard Troughton, Mark Richards, Robert N Doughty,  Carolyn SP Lam. The Singapore Heart Failure Outcomes and Phenotypes (SHOP) Study and Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction (PEOPLE) Study: Rationale and Design. J Card Fail 2013

4.      Ami N. Shah, Javed Butler, Andrew P. Ambrosy, Stefan D. Anker, Ovidiu Chioncel, Sean P. Collins, Wilfred Dinh, Gregg C. Fonarow, Robert J. Mentz, Carolyn S.P. Lam, Lothar Roessig, Naoki Sato, Mihai Gheorghiade. Designing Effective Drug and Device Development Programs for Hospitalized Heart Failure: A Proposal for Pre-trial Registries. J Am Coll Cardiol Heart Fail 2013

5.     Andrew P. Ambrosy, Gregg C. Fonarow, Ovidiu Chioncel, Stephen J. Greene, Muthiah Vaduganathan, Carolyn S.P. Lam, Naoki Sato, Ami P. Shah, Mihai Gheorghiade. The Global Health and Economic Burden of Hospitalizations for Heart Failure: Lessons Learned from HHF Registries. J Am Coll Cardiol 2013

6.   Javed Butler, Gregg C. Fonarow, Michael Zile, Carolyn Lam, Lothar Roessig, Erik Schelbert, Sanjiv Shah, Ali Ahmed, Robert Bonow, John GF Cleland, Robert Cody, Sean Collins, Preston Dunnmon, Gerasimos Filippatos, Martin Lefkowitz, Catherine N. Marti, John McMurray, Frank Misselwitz, Savina Nodari, Christopher O’Connor, Mark Pfeffer, Burkert Pieske, Bertram Pitt, Guiseppe Rosano, Hani N. Sabbah, Michele Senni, Scott Solomon, Norman Stockbridge, John Teerlink, Vasiliki V. Georgiopoulou, and Mihai Gheorghiade. Developing Therapies for Heart Failure with Preserved Ejection Fraction: Current State and Future Directions. J Am Coll Cardiol Heart Fail 2013

7.   Carsten Tschöpe and Carolyn S. P. Lam. Diastolic heart failure: What we still don’t know? Looking for new concepts, diagnostic approaches and the role of co-morbidities and sex differences. Herz 2012

8.    Carolyn S.P. Lam, Peter E. Carson, Inder S. Anand, Thomas S. Rector, Michael Kuskowski, Michel Komajda, Robert S. McKelvie, John J.McMurray, Michael R. Zile, Barry M. Massie, Dalane W. Kitzman. Sex Differences in Clinical Characteristics and Outcomes in Elderly Patients with Heart Failure and Preserved Ejection Fraction: The I-PRESERVE Trial. Circ Heart Fail. 2012 Sep 1;5(5):571-8

9.   Carolyn S.P. Lam; Philimon Gona; Martin G. Larson; Jayashri Aragam; Douglas S. Lee; Gary F. Mitchell; Daniel Levy; Susan Cheng; Emelia J. Benjamin; Ramachandran S. Vasan. Aortic Root Remodeling and Risk of Heart Failure in the Framingham Heart Study. JACC Heart Fail. 2013 Feb;1(1):79-83

10. Carolyn S.P. Lam, Dirk L. Brutsaert. Endothelial Dysfunction: A Pathophysiologic Factor In Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol. 2012 Oct 30;60(18):1787-9

11. Carolyn S.P. Lam, William C. Little. Sex and Cardiovascular Risk: Are Women Advantaged Or Men Disadvantaged? Circulation. 2012 Aug 21;126(8):913-5

12.  Rajalakshmi Santhanakrishnan, Jenny PC Chong, Tze P Ng, Lieng H Ling, David Sim, Kui Toh G Leong, Daniel Yeo, Hean Y Ong, Fazlur Jaufeerally, Raymond Wong, Chai Ping, Adrian F Low, Arthur Mark Richards, Carolyn SP Lam. Growth Differentiation Factor 15, ST2, high sensitivity Troponin T and N-terminal pro-B-type Natriuretic Peptide in Heart Failure with Preserved versus Reduced Ejection Fraction. Eur J Heart Fail. 2012 Aug 5. [Epub ahead of print]

13. Carolyn S.P. Lam, Asya Lyass, Elisabeth Kraigher-Krainer, Joseph M. Massaro, Douglas S. Lee, Jennifer E. Ho, Daniel Levy, Margaret M. Redfield, Burkert M. Pieske, Emelia J. Benjamin, Ramachandran S. Vasan.Cardiac and Non-Cardiac Dysfunction as Precursors of Heart Failure with Reduced and Preserved Ejection Fraction in the Community. Circulation. 2011 Jul 5;124(1):24-30

14. Carolyn S.P. Lam, Susan Cheng, Andrea D. Coviello, Martin G. Larson, Joanne M. Murabito, Christopher Newton-Cheh, Shalender Bhasin, Elizabeth L. McCabe, Karen K. Miller, Margaret M. Redfield, Ramachandran S. Vasan, Thomas J. Wang. Influence of Sex and Hormone Status on Circulating Natriuretic Peptides. J Am Coll Cardiol 2011;58:618–26

15.  Carolyn S.P. Lam. The Socioeconomics of Hyertension: How $50 000 May Buy A Drop In Blood Pressure. Invited editorial in Hypertension. 2011 Aug;58(2):140-1

16.  Selma F Mohammed; Jimmy R Storlie; Elise A Oehler; Lorna A Bowen; Josef Korinek; Carolyn Lam; Robert D Simari; John C Burnett, Jr.; Margaret M Redfield. Variable Phenotype in Murine Transverse Aortic Constriction (TAC). Cardiovasc Pathol. 2011 Jul 14.

17.  From AM, Lam CS, Pitta SR, Kumar PV, Balbissi KA, Booker JD, Singh IM, Sorajja P, Reeder GS, Borlaug BA. Bedside assessment of cardiac hemodynamics: the impact of noninvasive testing and examiner experience. Am J Med. 2011 Nov;124(11):1051-7

18.  Shah AM, Lam CS, Cheng S, Verma A, Desai AS, Rocha RA, Hilkert R, Izzo J, Oparil S, Pitt B, Thomas JD, Zile MR, Aurigemma GP, Solomon SD. The relationship between renal impairment and left ventricular structure, function, and ventricular-arterial interaction in hypertension. J Hypertens. 2011 Sep;29(9):1829-1836

19.  Abigail May Khan, Susan Cheng, Martin Magnusson, Martin G. Larson, Christopher Newton-Cheh, Elizabeth L. McCabe, Andrea D. Coviello, Jose C. Florez, Caroline S. Fox, Daniel Levy, Sander J. Robins, Pankaj Arora, Shalender Bhasin, Carolyn S.P. Lam, Ramachandran S. Vasan, Olle Melander, Thomas J. Wang. Cardiac Natriuretic Peptides, Obesity, and Insulin Resistance: Evidence from Two Community-Based Studies. J Clin Endocrinol Metab. 2011 Oct;96(10):3242-9

20. A Mark Richards, Carolyn Lam, Raymond Wong, Chai Ping. Heart Failure: A Problem Of Our Age. Ann Acad Med Singapore. 2011

21. Francesca Bursi, Sheila M. McNallan, Margaret M. Redfield, Vuyisile T. Nkomo, Carolyn S.P. Lam, Susan A. Weston, Ruoxiang Jiang, Véronique L. Roger. Pulmonary Pressures and Death in Heart Failure: A Community Study. J Am Coll Cardiol 2011 In press

22. Borlaug BA, Jaber WA, Ommen SR, Lam CS, Redfield MM, Nishimura RA. Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction. Heart. 2011 Jun;97(12):964-9

23.  Robert C Kaplan, Ann-Kristin Petersen, Ming-Huei Chen, Alexander Teumer, Nicole Glazer, Angela Döring, Carolyn S Lam, Nele  Friedrich, Anne Newman, Martina Müller, Qiong Yang, Georg Hohmuth, Anne Cappola, Norman Klopp, Holly Smith, Florian Ernst, Bruce M Psaty, H.-Erich Wichmann, Douglas B Sawyer, Reiner Biffar, Jerome I Rotter, Christian Gieger, Lisa S Sulivan, Henry Völzke, Kenneth Rice, Ariadni Spyroglu, Heyo K Kroemer, Ida Chen, Jenny Manolopoulou, Matthias Nauck, Mark Goodarzi, Martin Reincke, Martin Bidlingmaier, Ramachandran S Vasan, Henri Wallaschofski. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Hum Mol Genet. 2011 Mar 15;20(6):1241-51

24. Carolyn S.P. Lam, Xuan Liu, Qiong Yang, Martin G. Larson, Michael J. Pencina, Jayashri Aragam, Margaret M. Redfield, Emilia J. Benjamin, Ramachandran S. Vasan. Familial Aggregation of Left Ventricular Geometry and Association with Parental Heart Failure: The Framingham Heart Study. Circ Cardiovasc Genet. 2010 Dec 1;3(6):492-8

25. Barry A. Borlaug, Thomas P. Olson, Carolyn S.P. Lam, Kelly S, Flood, Amir Lerman, Bruce D. Johnson, Margaret M. Redfield. Global Cardiovascular Reserve Dysfunction in Heart Failure with Preserved Ejection Fraction. J Am Coll Cardiol 2010;56:845-54

26. Carolyn S.P. Lam, Vanessa Xanthakis, Lisa M. Sullivan, Wolfgang Lieb, Jayashri Aragam, Margaret M. Redfield, Gary F. Mitchell, Emelia J. Benjamin, Ramachandran S. Vasan.Aortic Root Remodeling Over the Adult Life Course:Longitudinal Data from the Framingham Heart Study. Circulation. 2010 Aug 31;122(9):884-90

27.  Carolyn S.P. Lam, Erwan Donal, Elisabeth Kraigher-Krainer, Ramachandran S. Vasan. Epidemiology and Clinical Course of Heart Failure with Preserved Ejection Fraction (Invited Review). Eur J Heart Fail. 2011 Jan;13(1):18-28

28.  Carolyn S.P. Lam, Ramachandran S. Vasan. Heart Failure Risk: Lessons from the Family (Invited Commentary). Congest Heart Fail 2010;16:139-40

29. Selma F. Mohammed, Tomohito Ohtani, Josef Korinek, Carolyn S.P. Lam, Katarina Larsen, Robert D. Simari, Maria L. Valencik, John C. Burnett Jr, Margaret M. Redfield. Mineralocorticoid Accelerates Transition to Heart Failure with Preserved Ejection Fraction Via “Non-Genomic Effects”. Circulation 2010;122:370-8

30. Barry A. Borlaug, Rick A. Nishimura, Paul Sorajja, Carolyn S.P. Lam, Margaret M. Redfield. Exercise Hemodynamics Enhance Diagnosis of Early Heart Failure with Preserved Ejection Fraction. Circ Heart Fail. 2010 Sep 1;3(5):588-95.

31. Carolyn S.P. Lam. Heart Failure with Preserved Ejection Fraction: Invasive Solution to Diagnostic Confusion? (Invited Editorial). J Am Coll Cardiol 2010;55:1711-2

32.  Carolyn S.P. Lam, Ming-Huei Chen, Sean M. Lacey, Qiong Yang, Lisa M. Sullivan, Vanessa Xanthakis, Radwan Safa, Holly M. Smith, Xuyang Peng, Douglas B. Sawyer, Ramachandran S. Vasan. Circulating Insulin-Like Growth Factor-1 and its Binding Protein-3:Metabolic and Genetic Correlates in the Community.Arterioscler Thromb Vasc Biol 2010;30:1479-84.

33.  Carolyn S.P. Lam, Jasmine Grewal, Barry A. Borlaug, Steve R. Ommen, Garvan C. Kane, Robert B. McCully, Patricia A. Pellikka. Size, Shape and Stamina: The Impact of Left Ventricular Geometry on Exercise Capacity. Hypertension. 2010;55:1143-9

34.  Grewal J, Lam C, Pellikka PA. Exercise Capacity and Left Ventricular Function Reply. JAMA 2009;301:2326-7

35. Carolyn S. P. Lam, Barry A. Borlaug, Garvan C. Kane, Richard J. Rodeheffer, Margaret M. Redfield. Age-Associated Increases in Pulmonary Artery Systolic Pressure in the General Population. Circulation 2009;119(20):2663-70.

36.  Carolyn S.P. Lam, Véronique L Roger, Richard J. Rodeheffer, Barry A. Borlaug, Felicity T. Enders, Margaret M. Redfield. Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction: A Community-Based Study. J Am Coll Cardiol. 2009;53:1119.

37.  Jasmine Grewal, Robert B. McCully, Garvan C. Kane, Carolyn Lam, Patricia A. Pellikka. Left Ventricular Diastolic Function Impacts Age-Based Differences in Exercise Capacity. JAMA 2009;301:286-94.

38. Carolyn S.P.Lam, Kenneth A. Tolep, Michael P. Metke, James Glockner, Leslie T. Cooper, Jr. Coronary Sarcoidosis Presenting as Acute Coronary Syndrome. Clin Cardiol. 2009;32(6):E67-E70.

39.  Barry A. Borlaug**, Carolyn S.P. Lam**, Veronique L. Roger, Richard J. Rodeheffer, Margaret M. Redfield. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol 2009;54(5):410-8.** Co-first authors

40.  Carolyn S.P. Lam. Diastolic heart failure: what, so what and now what? Ann Acad Med Singapore. 2009 Aug;38(8):663-6.

41. Jaber WA, Lam CS, Meyer DM, Redfield MM.Revisiting methods for assessing and comparing left ventricular diastolic stiffness: impact of relaxation, external forces, hypertrophy, and comparators.Am J Physiol Heart Circ Physiol. 2007;293(5):H2738-46.

42.  Brian P. Shapiro, Carolyn S.P. Lam, Jeetendra B. Patel, Selma F. Mohammed, Martina Kruger, Donna M. Meyer, Wolfgang A. Linke, Margaret M. Redfield. Acute and Chronic Ventricular-Arterial Coupling in Systole and Diastole: Insights From an Elderly Hypertensive Model. Hypertension. 2007;50(3):503-11.

43.  Lam CSP, Han L, Oh JK, Yang H, Ling LH. The Mitral Annular Mid-Diastolic Velocity Curve (L'): Functional Correlates and Clinical Significance in Patients with Left Ventricular Hypertrophy. J Am Soc Echocardiogr. 2008;21(2):165-70.

44.  Carolyn SP Lam, Véronique L Roger, Richard J Rodeheffer, Francesca Bursi, Barry A Borlaug, Steve R Ommen, David A Kass, Margaret M Redfield. Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation 2007;115(15):1982-90.

45. Carolyn SP Lam, John C Burnett, Lisa Costello-Boerrigter, Richard J Rodeheffer, Margaret M Redfield. Alternate Circulating ProBNP and BNP Forms in the General Population. J Am Coll Cardiol 2007;49(11):1193-202.

FUNDING SUPPORT

Principal Investigator, Asian Sudden Cardiac Death in Heart Failure (“ASIAN-HF” study); Investigator Sponsored Research Program (Boston Scientific) S$5.6 million

 

Co-investigator, Genetic Predilection, Epigenetic Change, MicroRNA Profiling and Experimental Therapies in Heart Failure: Theme 1 Genetic Markers for Heart Failure; National Medical

Research Council Translational & Clinical Research (TCR) Flagship Programme S$10 million

 

Principal Investigator, Biomarkers and Management of Cardiovascular Disease: Singapore Heart Failure Outcomes and Phenotypes (the "SHOP" study); National Medical Research Council Centre Grant S$6 million

 

Principal Investigator, Outcome in Patients with Heart Failure with a Preserved Left Ventricular Ejection Fraction (the “PEOPLE” study); A*STAR-NZ HRC S$250,000

 

Principal Investigator, Randomised, controlled pilot study to assess the role of IV ferric carboxymaltose in Asian patients with HF; Investigational Medicine Unit Bridging Fund S$60,000; Vifor Pharma educational grant S$95,000

 

Principal Investigator, REnal SymPathECTomy in Heart Failure (RESPECT-HF) Study, Medtronic ERP USD$250,000

 

Principal Investigator, Mechanistic Sub-Studies in SHOP and Early Phase Clinical Trials; Clinician Scientist Award S$670,000

 

Principal Investigator, Clinical Trials in Heart Failure, Clinician Scientist Award (SI) S$1.75 million