Principal Investigator: Associate Professor Chester Drum

MD, PhD.

 

Yong Loo Lin School of Medicine, NUS

 

Research Lab Profile:

Translational Innovation

 

Research Theme: 

Cardiac Pharmacology and Biomarkers

 

 

 

 

 






GROUP MEMBERS

  • Girish Vallerinteavide

  • Maya George

  • Charmaine Ng

  • Leroy Pakkiri

  • Goutam Chakraborty

  • Liu Hui Hui

  • Priya Desai

  • Jackson Low

  • Mylene Pestano

  • Vimala Sadaiyappan

  • Ritchel Andeza

  • Nihar Mazurkar

  • Michael Ding

  • Mai Chin Lo


PUBLICATIONS

Drum CL. System-level prescriptions for adaptive drug licensing. Science Translational Medicine. 2015 Mar 04;7(277):277ec36.

Drum CL. TRIPOD puts prediction models on a firmer footing. Science Translational Medicine. 2015 Jan 28;7(272):272ec14–4.

Tao D, Hong M, Richards AM, Wong TI, Zhou X, Drum CL. Quantification of a cardiac biomarker in human serum using extraordinary optical transmission (EOT). PloS ONE. (in press, accepted 2015 Jan 29).

Drum CL. TRIPOD puts prediction models on a firmer footing. Science Translational Medicine. 2015 Jan 28;7(272):272ec14–4.

Chan JM, Wong KHK, Richards AM, Drum CL. Microengineering in Cardiovascular Disease: new developments and translational applications. Cardiovascular Research. 2015 Feb 17; 49 (epub ahead of print)

Drum CL. Watch your leftovers: Remnant cholesterol brings oversized risk to cardiovascular health. Science Translational Medicine. 2014 Dec 3;6(265):205.

Drum CL. Short circuiting mitochondria leads to improvement in mouse models of diabetes. Science Translational Medicine. 2014 Oct 22;6(259):179.

Drum CL. The ubiquitinase pathway takes center stage in viral myocarditis. Science Translational Medicine. 2014 Sep 10;6(253):155.

Yu J, Tao D, Ng EX, Drum CL, Liu AQ, Chen C-H. Real-time measurement of thrombin generation using continuous droplet microfluidics. Biomicrofluidics. 2014 Sep;8(5):052108.

Drum CL. Long non-coding RNAs in myocardial infarction. Science Translational Medicine. 2014 Jul 30;6(247):131.

Drum CL. Taking Cancer Cells Out of Circulation. Science Translational Medicine. 2014 Jun 18;6(241):104.

Drum CL. Magnetic Resonance: It’s a Gas! Science Translational Medicine. 2014 May 7;6(235):80.

Drum CL. Getting to the Heart of Consciousness. Science Translational Medicine. 2014 Mar 26;6(229):53.

Eichler H-G, Oye K, Baird LG, Abadie E, Brown J, Drum CL, et al. Adaptive licensing: taking the next step in the evolution of drug approval. Clin Pharmacol Ther. 2012 Mar;91(3):426–37.

De Sousa FB, Lima AC, Denadai AML, Anconi CPA, De Almeida WB, Novato WTG, et al. Superstructure based on β-CD self-assembly induced by a small guest molecule. Phys Chem Chem Phys. The Royal Society of Chemistry; 2012 Feb 14;14(6):1934–44.

Chan JM, Rhee J-W, Drum CL, Bronson RT, Golomb G, Langer R, et al. In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl Acad Sci USA. National Acad Sciences; 2011 Nov 29;108(48):19347–52.

Shen Y, Guo Q, Zhukovskaya NL, Drum CL, Bohm A, Tang W-J. Structure of anthrax edema factor-calmodulin-adenosine 5′-(alpha,beta-methylene)-triphosphate complex

reveals an alternative mode of ATP binding to the catalytic site. Biochem Biophys Res Commun. 2004 Apr 30;317(2):309–14.

Drum CL, Yan S-Z, Bard J, Shen Y-Q, Lu D, Soelaiman S, et al. Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 2002 Jan 24;415(6870):396–402.

Drum CL, Shen Y, Rice PA, Bohm A, Tang WJ. Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin. Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1881–4.

Drum CL, Yan SZ, Sarac R, Mabuchi Y, Beckingham K, Bohm A, et al. An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis. J Biol Chem. American Society for Biochemistry and Molecular Biology; 2000 Nov 17;275(46):36334–40.

Tang WJ, Yan S, Drum CL. Class III adenylyl cyclases: regulation and underlying mechanisms. Adv Second Messenger Phosphoprotein Res. 1998;32:137–51.

Benzinger GR, Drum CL, Chen LQ, Kallen RG, Hanck DA, Hanck D. Differences in the binding sites of two site-3 sodium channel toxins. Pflugers Arch. 1997 Nov;434(6):742–9.

Kelso GJ, Drum CL, Hanck DA, Blumenthal KM. Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel. Biochemistry. 1996 Nov 12;35(45):14157–64.

Dias-Kadambi BL, Combs KA, Drum CL, Hanck DA, Blumenthal KM. The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B. J Biol Chem. 1996 Sep 27;271(39):23828–35.

Dias-Kadambi BL, Drum CL, Hanck DA, Blumenthal KM. Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel. J Biol Chem. 1996 Apr 19;271(16):9422–8.

Khera PK, Benzinger GR, Lipkind G, Drum CL, Hanck DA, Blumenthal KM. Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination. Biochemistry. 1995 Jul 11;34(27):8533–41.