Principal Investigator: Associate Professor Mark Y. Chan

MBBS (S'pore), MHS (USA), MMED (Int Med), MRCP (UK)

Senior Consultant Department of Cardiology, NUHCS

Associate Professor of Medicine Yong Loo Lin School of Medicine, NUS


Research Lab Profile:

Acute coronary Syndrome

Platelets

Coagulation

Biomarkers

 

Research Theme: 

Acute Coronary Syndrome and Platelets Coagulation Biomarkers

 

 

 

 

GROUP MEMBERS

  • Leonardo Carvalho
  • Aruni Seneviratna
  • Tan Sock Hwee
  • Yang Xiaoxun
  • Fong Chin Fah
  • Teo Zhen Long
  • Poh Sock Cheng
  • Daphne Liang

 

COLLABORATORS

  • Heng Chew Kiat (NUS)
  • Veronique Angeli (NUS)
  • Dominique de Kleijn (NUS)
  • Kini R. Manjunatha (NUS)
  • Matthew T. Roe (Duke University Durham, NC)
  • Svati S. Shah (Duke University, Durham, NC)
  • Alan Fong (Sarawak General Hospital, Kuching, MY)
  • Bryan Yan (Chinese University of Hong Kong, Kowloon, HK)
  • Chin Chee Tang (National Heart Centre, Singapore)
  • Richard Troughton (Christchurch Heart Centre, Christchurch, NZ)
  • Jeong Young Hoon, Gyeongsang, Korea
  • Markus Wenk (NUS)
  • Ching Jianhong (Duke-NUS) 
  • Sam Li (NUS)
  • Patricia Nuttall (Oxford, UK)
  • Vitaly Sorokin (NUS)
  • Vladimir A. Kuznetsov (A*star)
  • Christine Cheung (A*star)
  • Chow Khuan Yew (National Registry of Disease Office)
  • Ho Hee Hwa (Tan Tock Seng Hospital)
  • Tai Bee Choo (Saw Swee Hock School of Public Health)

PUBLICATIONS

Selected from 60:

Mark Y. Chan, Karen Tan, et al: Functional Significance and Differential Prevalence of CYP2C19 and PON1 Polymorphisms Regulating Clopidogrel Bioactivation in Chinese, Malay and Indian Subjects. Pharmacogenomics 2012


Mark Y. Chan, Mauricio G. Cohen, Christopher K. Dyke, Shelley K. Myles, Laura G. Aberle, Min Lin, Nicholas Chronos, Chiara Melloni, John H. Alexander, Robert A. Harrington, Ross M. Tonkens, James Walden, Steven R. Steinhubl, Ian C. Gilchrist, Neal S. Kleiman, David A. Vorchheimer, Richard C. Becker, and Christopher P. Rusconi: A Phase 1b Randomized Study of Antidote-Controlled Modulation of Factor IXa Activity in Patients with Stable Coronary Artery Disease. Circulation. 2008; 117: 2865-2874


Mark Y. Chan, Bimal R. Shah, Fei Gao, Ling Ling Sim, Terrance Chua, Huay Cheem Tan, Tiong Cheng Yeo, Hean Yee Ong, David Foo, Ping Ping Goh, Soondal K. Surrun, Karen S. Pieper, Christopher B. Granger, Tian Hai Koh, Agus Salim, and E Shyong Tai: Recalibration of the Global Registry of Acute Coronary Events Risk Score in a Multi-ethnic Asian Population. Am Heart J 2011


Mark Y. Chan, Lena J. Sun, L. Kristin Newby, Linda K. Shaw, Min Lin, Eric D. Peterson, Robert M Califf, David F. Kong, and Matthew T. Roe. Long-Term Mortality of Patients Undergoing Cardiac Catheterization for ST-elevation and Non ST-elevation Myocardial Infarction. Circulation 2009;119:3110-3117


Yiding Li, Bee-Choo Tai, Winnie Sia, Qian-Hui Phua, Mark A. Richards, Adrian Low, Koo-Hui Chan, Swee-Guan Teo, Tiong-Beng Sim, Chi-Hang Lee, Matthew T. Roe, Tiong-Cheng Yeo Huay-Cheem Tan and Mark Y. Chan: Angiographic and Platelet Reactivity Outcomes with Prasugrel 60 mg Pretreatment and Clopidogrel 600 mg Pretreatment in Primary Percutaneous Coronary Intervention.  Journal of Thrombosis and thrombolysis 2012


Mark Y. Chan, Min Lin, Joseph Lucas, Arthur Moseley, J. Will Thompson, Derek Cyr, Hitoshi Ueda, Mariko Kajikawa, Thomas L. Ortel and Richard C Becker: "Plasma Proteomics of Patients with Non-valvular Atrial Fibrillation on Chronic Anti-coagulation with Warfarin or a Direct Factor Xa Inhibitor". Thrombosis and Haemostasis 2012


Mark Y. Chan, MBBS, MRCP, MHS, Jie-Lena Sun, MS, L. Kristin Newby, MD, MHS, Yuliya Lokhnygina, PhD, Harvey D. White, MB, ChB, DSc, David J. Moliterno, MD, Pierre Théroux, MD, E. Magnus Ohman, MB, ChB, Maarten L. Simoons, MD, Kenneth W. Mahaffey, MD, Karen S. Pieper, MS, Robert P. Giugliano, MD, SM, Paul W. Armstrong, MD, Robert M. Califf, MD, Frans Van de Werf, MD, PhD, Robert A. Harrington, MD: Trends in clinical trials of non–ST-segment elevation acute coronary syndromes over 15 years. Int J Cardiol 2012


Pinto de Carvalho L, McCullough PA, Gao F, Sim LL, Tan HC, Foo D, Ooi YW, Richards AM, Chan MY, Yeo TC: Renal function and anaemia in acute myocardial infarction. Int J Cardiol. 2013


A Single Centre Experience of Transitioning from a Routine Transfemoral to a Transradial Intervention Approach in ST-Elevation Myocardial Infarction: Impact on Door-to-Balloon Time and Clinical Outcomes

Takashi Kajiya, Fransisca Agahari, Khin Lay Wai, Bee-Choo Tai, Chi-Hang Lee, Koo-Hui Chan, Swee Guan Teo, A. Mark Richards, Huay-Cheem Tan, Adrian F. Low and Mark Y. Chan. Journal of Cardiol 2013


Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy.

Gurbel PA, Erlinge D, Ohman EM, Neely B, Neely M, Goodman SG, Huber K, Chan M Y, Cornel JH, Brown E, Zhou C, Jakubowski JA, White HD, Fox KA, Prabhakaran D, Armstrong PW, Tantry US, Roe MT; TRILOGY ACS Platelet Function Substudy Investigators. JAMA. 2012 Nov 7;308(17):1785-94 

 

de Carvalho LP1, Gao F, Chen Q, Hartman M, Sim LL, Koh TH, Foo D, Chin CT, Ong HY, Tong KL, Tan HC, Yeo TC, Yew CK, Richards AM, Peterson ED, Chua T, Chan MY. Differences in late cardiovascular mortality following acute myocardial infarction in three major Asian ethnic groups. 1-Eur Heart J Acute Cardiovasc Care. 2014.


FUNDING SUPPORT

  1. NMRC Singapore. Bridging Discovery to development of a novel direct thrombin inhibitor. Total cost: SGD 1.5 million. Term: 2014-2017. Role: P.I.
  2. NMRC Singapore. Improving reModeling in Acute Myocardial Infarction through Telemedicine and Novel Treatments (IMMACULATE trial). Total cost: SGD 5 million. Term 2014-2019. Role: co-I
  3. A*star, Singapore. Title: Genome-wide association study of CAD in Asians. S$1,000,000. Term: 5 years. Role: co-I.
  4. Roche Diagnostics. Platelet Reactivity Testing in Asians. Euro 70,000. Term: 2 years. Role. PI.
  5. National Medical Research Council Translational Clinical Research Grant. Plasma miRNA profiles of LV  remodeling following STEMI. 3 year term. Total cost: $550,000. Role. Co.I.
  6. National Medical Research Council, Singapore. Title: Predicting Outcomes in Acute Coronary Syndromes. Total cost: $675,000. Term: 3/2011-3/2014. Role: P.I.
  7. Eli-Lilly, Indianapolis, IN. Title: TRILOGY-ACS Advanced Biomarkers Substudy. Term: 9/2011-6/2014. Total cost: US$1,400,000. Role. Co-P.I.
  8. NMRC Singapore. NUHCS Centre Grant. Total cost: SGD 1 million. Term: 2013-2016. Role. Co-P.I.