Principal Investigator: Professor A. Mark Richards

BChB, MD (Distinction), PhD, DSc, FRACP, FRCP,FAHA, FRSNZ

Director, Cardiovascular Research Institute (CVRI), NUHS
Professor of Cardiovascular Studies, National Heart Foundation of NZ
Consultant in Cardiology, Canterbury District Health Board
Professor in Medicine (Personal Chair), Department of Medicine, University of Otago, Christchurch

 

Research Lab Profile:

In addition to his role as director of the CVRI, Professor Richards leads a group focused upon discovery and assay of cardiovascular biomarkers. These extend from signal peptides, and cytokines to circulating microRNA profiles all under assessment for diagnostic, prognostic and monitoring applications in an array of cardiovascular conditions including acute and chronic phases of heart failure, heart valve disease and coronary artery disease.

 

Assay development in clinical cohorts parallels investigation of in vitro and in vivo models of cardiovascular disease.


Research Theme:

Heart Failure Biomarkers. Circulating Peptides

 

GROUP MEMBERS

Senior Staff
  • Dr Liew Oi Wah, Senior Scientist (antigen cloning, assay development)
  • Dr Eliana Martinez, Research fellow (novel markers and treatments in rat models of post-infarction heart failure)
  • Dr Peipei Wang, Senior Scientist (isolated [Langendorff] perfused heart model, mechanisms of cardioprotective agents)
  • Dr Y T Chen , Senior Scientist (in vitro models of cardiac stress, modulators of neurohormonal response)
  • Dr Leelee Wong, Research Fellow (microRNA studies for diagnosis and prognosis in heart disease)
Post-doctoral and PhD staff
  • Zhou Yue
  • Jin Bo
  • Shera Lilyanna
  • Technical and Research Assistant Staff
  • Jenny Chong Pek Ching, Head Technologist,
  • Ng Yan Xia, Jessica
  • Peh Yu Pei
  • Lew Kar Sheng, Jason
  • Chen Qiying
  • Wee Shun Yuh
  • Lim Xia Yuen

COLLABORATORS

  • Professor Kandiah Jeyaseelan, Biochemistry, YLL SoM
  • Professor P Too, Biochemistry, YLL SoM
  • Professor Tim Yandle, University of Otago, Christchurch, New Zealand
  • Prof Zoltan Endre, University of new South Wales, Sydney
  • Multiple other investigators in over 15 countries as co-members of biomarker consortia co-founded or joined by Professor Richards and his teams in both Singapore and New Zealand ICON, BACH, GREAT and HOMAGE
 

PUBLICATIONS

LIEW OW, ANG CX, PEH YP, CHONG PCJ, NG YX, ANG LA H-W,KOH XU, YIP YM, LIU W, RICHARDS AM. A His6-SUMO-eXact Tag for Producing Human Prepro-Urocortin 2 in Escherichia coli for Raising Monoclonal Antibodies J Immun Methods (in press) 2013.

LAM CS, ANAND I, ZHANG S, SHIMIZU W, NARASIMHAN C, PARK SW, YU CM, NGARMUKOS T, OMAR R, REYES EB, SISWANTO B, LING LH, RICHARDS AMAsian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry. Eur J Heart Fail. 2013 Aug;15(8):928-36. doi: 10.1093/eurjhf/hft045.

TAN HT, LING LH, RICHARDS AM, CHUNG MCM. Proteomics Discovery of Biomarkers For Mitral Regurgitation Caused By Mitral Valve Prolapse Journal of Proteomics 2013;16. doi:pii: S1874-3919(13)00518-6. 10.1016/j.jprot.2013.10.009

TAN A, HAU W, HO H-H, GHAEM M, HALEH LOO, GERMAINE K, SEE M, TAI B-C, RICHARDS M, ONG P, LEE CHI-HANG. Obstructive Sleep Apnea and Coronary Plaque Characteristics. CHEST (in press) 2013.

CARVALHO L, GAO F, CHEN Q, HARTMAN M, SIML-L, KOH T-H, FOO D, CHIN C-T, ONGH-Y, TONG K-L, TAN H_C, YEO T-C,YEW C-K, RICHARDS AM, PETERSON ED, CHUA T, CHAN MY. Late Cardiovascular Mortality Following Acute Myocardial Infarction in Three Major Asian Ethnic Groups Eur Heart J: acute cardiovascular disease (in press) 2013.

ELLIS KL, CAMERON VA, TROUGHTON RW, FRAMPTON CM, ELLMERS LJ, RICHARDS AM. Circulating microRNAs as Candidate Markers to Distinguish Heart Failure in Breathless Patients. Eur J Heart Fail.2013;15:1138-47.

SANTHANAKRISHNAN R, NG TP, CAMERON VA,GAMBLE GD, LING LH, SIM D, LEONG GKT, YEO PSD, ONG HY, JAUFEERALLY F, WONG RC-C, CHAI P, LOW AF, LUND M ,DEVLIN G, TROUGHTON R, RICHARDS AM, DOUGHTY RN, LAM CSP. The Singapore Heart Failure Outcomes and Phenotypes (SHOP) Study and Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction (PEOPLE) Study: Rationale and Design. J Cardiac Failure 2013;19:156-62.

CHAN KKN, PATEL RS, NEWCOMBE P, NELSON CP, ALLAYEE H ELLIS KL , SHEN G-Q, GONG Y, LAXTON RC, WITTAKER JC, JOHNSON JA, WANG QK, ASSIMES TL, NÖTHLINGS U, FARRALL M, WATKINS H,RICHARDS AM, CAMERON AV, DREXEL H, KOCH W, KIMURA A, SHEN W, QUYYUMI AA, HAZEN SL, HORNE BD, HAUSER ER, REILLY MP, SAMANI NJ, SHU YE. Association between 9p21 and Angiographic Coronary Artery Disease – A Collaborative Meta-analysis J Am Coll Cardiol 2013;61:957-970.

SIRIWARDENA M, CAMPBELL V, RICHARDS AM, PEMBERTON CJ B-type Natriuretic Peptide signal peptide (BNPsp) and high sensitivity troponin T (hsTnT) responses to dobutamine stress echocardiography Clin Chem 2012 ;58:1492-4.

SANTHANAKRISHNAN R, CHONG JPC, NG TP, LING LH, SIM D, LEONG KTG, YEO D, ONG HY, JAUFEERALLY F, WONG R, PING C, LOW AF, RICHARDS AM, LAM CSP. Growth Differentiation Factor 15, ST2, high sensitivity Troponin T and N-terminal pro-B-type Natriuretic Peptide in Heart Failure with Preserved versus Reduced Ejection Fraction Eur J Heart Failure 2012;14:1338-47.

LEE CH, WK HAU, TAI BC, CHAN MY, SAW B, PHUA QH, LOW AF, YEO TC, RICHARDS AM, TAN HC. Adiponectin Profile in Asian Patients Undergoing Coronary Revascularization and Its Association with Plaque vulnerability Obesity 2012;20:2451-2457. doi:10.1038/oby.2012.92.

FUNDING SUPPORT

NMRC Centre Grant to NUHCS ,”Heart Failure: mechanisms and management” S$10 M 2013-17.

NMRC TCR Grant “Genetics, Epigentics, micro RNA profiling and Experimental Therapies in Heart Failure” S$9M 2013-2018.

HRC (NZ) Heart Failure Research Programme, NZ$ 3.5M 2011-14.

HRC (NZ) Grant , Renal denervation in Heart Failure with Preserved Ejection Fraction (“RESPECT-HF”) NZ$ 1.2M 2013-2016.

Industry and start up support also underpins several initiatives undertaken by the CVRI.