Principal Investigator: Associate Professor Roger Foo

M.D., M.B.B.S., M.R.C.P., F.A.H.A.

Associate Professor of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

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Senior Consultant, Cardiac Department, National University Heart Centre, Singapore

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Senior Investigator, Genome Institute of Singapore (GIS)


Research Lab Profile:

Laboratory of Cardiac Epigenome and Molecular Epigenetics

Foo-lab.com

 

Research Theme: 

Heart Failure Epigenomics, Molecular Epigenetic and Stress-Gene Response

 

 

 

 

GROUP MEMBERS

 

Post-doctoral Fellows:

  • Kelvin See, PhD (AGS-NUS, Singapore)
  • Matias Autio, PhD (Imperial College, UK) 
  • Matt Ackers-Johnson, PhD (Cambridge, UK) 
  • Eleanor Huijin Wong, PhD (NUS, Singapore) 
  • Rongrong Zhao, PhD (Cambridge, UK)
  • Benson Lim, PhD (Melbourne, Australia)
  • Malin Jonsson, PhD (Utrecht, Netherlands)
  • Chukwuemeka George Anene-Nzelu, PhD (NUS, Singapore)

Research Associates and Assistants:

  • Peter Yiqing Li, BSc (UWA, Australia) - CBS Manager
  • Tuan Luu Danh Anh, DM (Vietnam) - CBS Surgeon
  • Zenia Tiang, BSc (NUS, Singapore) - Lab Manager
  • Wilson Lek Wen Tan, BSc (NUS, Singapore) - Computation and Bioinformatics
  • Jyn Ling Kuan, BSc (UM, Malaysia) - Computation and Bioinformatics
  • Suzanne Hui San Tan, BSc (St Andrew’s, UK)
  • Pan Bangfen, MSc (Shanghai)
  • Ellen Tejo, DipBiotech (Republic Polytechnic, Singapore)
  • Ruifeng Wang, Dip Nursing - Lab Administrator
  • Ng Shi Ling, BSc (Western, Australia)
  • Edita Aliwarga, BSc (AJCU, Indonesia)
PhD Students:
  • Albert Dashi, MSc (Bern, Switzerland): SINGA Scholar
  • Ning Ding, MPhil (Cambridge, UK): NUS Research Scholar
  • Dominic Paul Kok Sheng Lee, BSc (Monash, Australia): NUS Research Scholar
  • Oliver Jaime Worsley, BSc (Edinburgh, UK): SINGA Scholar
  • Cheryl Xueli Chan, BSc (NTU, Singapore): A*STaR NSS Scholar
  • Lim Choon Kiat, MSc (NTU, Singapore): A*STaR NGS Scholar

Interns (present and past):

  • Lavani, BSc (NUS, Singapore).
  • Wei Qiang Seow, BSc (NUS, Singapore). Presently, A*STaR PhD Scholar at Cambridge, UK.
  • Shing Pheng Lam (Ngee Ann Polytechnic). 
  • Phillina Yihui Phua (Ngee Ann Polytechnic). 
  • Chunjie Wong (Hwa Chong Institution).
  • Yee Shiun Chan (NUS High School).
  • Benjamin Lee (LKC Medical School).
  • Daobo Wang (YLL School of Medicine)
  • Raphael Soh (Raffles Institution)
  • Kritchai Vutipongsatorn (Temasek JC). Presently, Imperial College London Medical School
  • Li Ting Lee (Temasek Polytechnic). 
  • Jade Tangqi Ng (Murdoch University)
  • Nicole Yuk Yin Choi (Ngee Ann Polytechnic)
  • Ser Ning Poh (Ngee Ann Polytechnic)
  • Jing Han Ng (YLL Medicine)
  • Yi Hao Nah (Republic Polytechnic)
Past group members:
  • Dr Lee Siggens (PhD student). Presently, post-doctoral fellow at Karolinska Institutet.
  • Dr Ana Vujic (PhD student). Presently, post-doctoral fellow at Harvard Stem Cell Institute.
  • Dr Mehregan Movassagh (Post-doctoral fellow). Presently at Prescient Life Sciences.
  • Dr Lina Cordeddu (Post-doctoral fellow). Presently, post-doctoral fellow at Karolinska Institutet.
  • Emma Robinson (PhD student). Presently completing her PhD at Babraham Institute, Cambridge.
  • Dr Justus Stenzig (Post-doctoral fellow). Presently at University Medical Center Hamburg-Eppendorf).
  • Wee Woon Chua, DipBiotech (Singapore Polytechnic) – Lab Manager

 


COLLABORATORS

  • A/Professor Theo Kofidis (NUS)
  • A/Professor James Yip (NUS)
  • Dr Raymond Wong (NUHC)
  • Dr Swee Chye Seow (NUH)
  • A/Professor Quek Swee Chye (NUS)
  • Dr Robert Grignani (NUH)
  • Dr Terence Lim (NUH)
  • Professor Colin Stewart (IMB, Singapore)
  • Dr Christine Cheung (IMCB, Singapore)
  • Dr Angeline Lai (KKH, Singapore)
  • Professor Yibin Wang (UCLA)
  • Professor Elisabeth Zeisberg (Gottingen)
  • Professor Christopher Huang (Cambridge)
  • Professor Martin Bennett (Cambridge)
  • Dr Martin Goddard (Papworth Hospital, Cambridge 

FUNDING SUPPORT

  • Senior Clinician Scientist Award, NMRC
  • NUHS Cardiology Centre Grant, NMRC
  • Cardiovascular Translational & Clinical Research Flagship grant, NMRC
  • NUHS Seed Grant
  • CS-IRG, NMRC
  • A*STaR Biomedical Research Centre, Strategic Programme Fund

PUBLICATIONS

1.     Pilbrow AP, Cordeddu L, Cameron VA, Frampton CM, Troughton RW, Doughty RN, Whalley GA, Ellis CJ, Yandle TG, Richards AM, Foo RS. Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. Int J Cardiol. 2014 Jul 22. pii: S0167-5273(14)01276-5

2.     Rachmin I, Tshori S, Smith Y, Oppenheim A, Marchetto S, Kay G, Foo RS, Dagan N, Golomb E, Gilon D, Borg JP, Razin E. Erbin: a negative regulator of cardiac hypertrophy.Proc Natl Acad Sci. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5902-7.

3.     Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Bauer R, Caamaño JH, Figg N, Foo RS, Mann J, Mann DA, Oakley F. The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. Am J Pathol. 2012 Mar;180(3):929-39.

4.     Fernandez-Twinn DS, Blackmore HL, Siggens L, Giussani DA, Cross CM, Foo R, Ozanne SE. The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation. Endocrinology. 2012 Dec;153(12):5961-71. doi: 10.1210/en.2012-1508. Epub 2012 Oct 15.

5.     S. Haider, L. Cordeddu, A. Vujic, L. Siggens, R.S. Foo. Landscape of repetitive element methylation in human heart failure. Genome Biology. 2012 Oct 3;13(10):R90. (IF: 9.04)

6.     L. Siggens, N. Figg, M. Bennett, R.S. Foo. Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1. FASEB J.2012 Feb 1. (IF: 6.401)

7.     M. Movassagh, M-K. Choy, D Knowles, L. Siggens, A. Vujic, T. Down, M. Goddard, M. Bennett, R.S. Foo. Distinct epigenomic features in human end-stage failing human hearts. 2011. Circulation2011 Nov 29;124(22):2411-22.

8.     M-K. Choy, M. Movassagh, R.S. Foo. The human variome: genomic and epigenomic diversity. EMBO Mol Med. 2011 Oct;3(10):573-4.

9.     M. Movassagh, A. Vujic, R.S. Foo. The 5th nucleotide: DNA methylation and heart failure. Epigenomics. 2011 Feb 3(1): 103-9.

10.     M-K. Choy, M. Movassagh, H-G. Goh, M.R. Bennett, T.A. Down, R.S. Foo. Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated.BMC Genomics2010 Sep 27;11(1):519.

11.     R.S. Foo. Basic mechanisms in apoptosis and heart failure. Heart and Metabolism. 2010.

12.     M-K. Choy, M. Mossavagh, M. Goddard, A.M. Sanchez, N.D. Perkins, N. Figg, M.R. Bennett, J.S. Carroll, R.S. Foo. p53 piggy-backs onto NF-kB to regulate microRNA-21 expression. Genome Med. 2010 Jun 14;2(6):37.

13.     M-K. Choy, M. Mossavagh, J.P. de Bono, K.M. Channon, M.R.Bennett, R.S. Foo. Akt activation inhibits p53-mediated Hif1a degradation that independent of MDM2. J Cell Physiol. 2010 Mar;222(3):635-9.

14.     M. Movassagh, T.A. Down, M-K. Choy, M. Goddard, M.R. Bennett, R.S. Foo. Differential methylation correlates with differential expression of angiogenic factors in human heart failure. PLoS One. 2010 Jan 13;5(1):e8564.

15.     Harzheim D, Talasila A, Movassagh M, Foo RS, Figg N, Bootman MD, Roderick HL. Elevated InsP(3)R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes. Channels (Austin). 2010 Jan 17;4(1).

16.     Harzheim D, Movassagh M, Foo RS, Ritter O, Tashfeen A, Conway SJ, Bootman MD, Roderick HL. Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11406-11. 

17.     M. Movassagh, R.S. Foo. Simplified apoptotic cascades. Heart Fail Rev2008 Jun;13(2):111-9.

18.     R.S-Y. Foo, Y. Nam, M.J. Ostreicher, M.D. Metzl, R.S. Whelan, C. Peng, A.W. Ashton, W. Fu, S.-F. Chin, E. Provenzano, I. Ellis, N. Figg, S. Pinder, M. Bennett, C. Caldas, R.N. Kitsis. Regulation of p53 tetramerization and nuclear export by ARC. Proc Natl Acad Sci USA2007 Dec 26;104(52):20826-31

19.     R. S. Foo, L. Chan, R.N. Kitsis, M.R. Bennett. Ubiquitination and degradation of ARC by MDM2. J Biol Chem 2007 Feb 23;282(8):5529-35.

20.     Y.J. Nam, K. Mani, L. Wu, R. S-Y. Foo, C.F. Peng, B Krishnamoorthy, W. Miao, A. Ashton, R Kitsis. Identification of a degradation-resistant ARC mutant. J Biol Chem. 2007 Feb 23;282(8):5522-8.

21.     R.S Foo, R. Siow, M.J. Brown, M.R. Bennett. Heme oxygenase-1 gene transfer inhibits angiotensin II mediated rat cardiomyocyte apoptosis but not hypertrophy. J Cell Physiol. 2006 Oct;209(1):1-7

22.     R.S. Foo, K. Mani, R.N. Kitsis. Death begets heart failure. J Clin Invest. 2005 Mar;11:565-71


PRESS

  • New clinic helps diagnose those with inherited heart conditions. September, 2014 (link)
  • Environment and diet leave their prints on the heart. November, 2011 (link)
  • “Missing link” between heart failure and environment discovered. January, 2010 (link)